O:PAIRS is a worldwide initiative to establish a strong base of clinical evidence on the ex vivo preservation of kidneys for transplantation. Sponsored by Organ Recovery Systems and led by eminent physician-scientists, O:PAIRS comprises three independent landmark outcomes trials. Each follows a naturalistic study design, separating pairs at recovery to compare patient outcomes from machine-perfused versus static-stored kidneys. Each targets immediate and delayed graft function as primary endpoints and longer-term graft function and survival as secondary endpoints. Each will deliver the rigor possible only in a large, prospective, randomized, controlled, powered clinical trial. And each exclusively features the award-winning, easy-to-use LifePort Kidney Transporter.


Belgium, The Netherlands, Germany
The Machine Preservation Trial stands foremost in the O:PAIRS group: the first large, international, multicenter clinical trial to investigate the relative efficacy and cost-effectiveness of machine versus static preservation. The trial was conducted in Germany, The Netherlands, and Belgium in collaboration with Eurotransplant and the Deutsche Stiftung Organtransplantation. Start 1 November 2005. End 1 November 2006. Coordinating PI: Rutger Ploeg. N=600 recipients.

Results from the landmark Machine Preservation Trial published in the New England Journal of Medicine in 2009 demonstrated for the first time that use of a LifePort can reduce the odds of experiencing a delay in recovery of kidney function by 43 percent. In addition, these kidneys are 48 percent less likely to fail within a year compared to those stored in the traditional box of ice.(i) These results build upon those from retrospective studies showing that machine preservation improves the quality of a kidney from a cadaveric donor prior to transplantation in comparison to those stored in a cool box.(ii)

(i)Moers C, Smits JM, Maathuis M-HJ et al. Machine perfusion or cold storage in deceased-donor kidney transplantation. N Engl J Med 2009; 360: 7-19.
(ii) Schold JD etal. Are we frozen in time? Analysis of the utilization and efficacy of pulsatile perfusion in renal transplantation. Am J Transpl 2005; 5: 1681-1688.

MPT Abstracts
ATC 2008
ATC 2009 - Long Term Cost Effectiveness
ATC 2009 - MP vs. CS in NHBD
ATC 2009 - MP vs. CS in Older Donors
ESOT 2007
ESOT 2009 - MP vs CS
ESOT 2009 - RR during MP
ESOT 2009 - MPT - Angiopoietin Plasma Analyses
ESOT 2009 - MPT Short and Long Term Cost-Effectiveness Analysis
ESOT 2009 - MPT tGST and HFABP Perfusate Analyses
ITC 2008 - MPT CE
ITC 2008 - MPT NHBD
ITC 2008 - MPT ODD

Stay tuned to www.organpreservation.nl for MPT news.